Novel potentiometric methods for the estimation of bisoprolol and alverine in pharmaceutical forms and human serum

Abstract Two new potentiometric sensors were created for the quantification of bisoprolol fumarate and alverine citrate in bulk pharmaceutical dosage forms human serum. Bisoprolol manufactured by combining potassium tetrakis ( p -chlorophenyl) borate ion pairs to serve as electroactive substances, plasticized poly (vinyl chloride) matrix membranes, o -nitrophenyl octyl ether. They demonstrated high responses over concentration ranges 1.0×10 ?6 ?2 mol L ?1 with close Nernstian cationic slopes 52 56 mV decade , respectively. The detection limits 2.6×10 1.75×10 For both medications, response time was instantaneous (2.0 s). working pH 4.50–8.50 2.00–8.80, sensors, life cycle long (3 months). used types assay alverine, recording average recoveries 99.40% 99.98% respectively also successfully estimating two drugs serum an recovery 99.60% drugs. all multiple staged interfering materials, reported latest sensor methods displayed selectivity. current obtained a percentage excellent relative standard deviation compared those from previously published methods.